Trulicity (Dulaglutide)

1. Pronunciation & Basic Information

• Pronunciation: TRU-li-si-tee
• Generic name: Dulaglutide
• Drug class: GLP-1 receptor agonist
• Dosage form: Single-use prefilled pen for subcutaneous injection
• Available strengths:
  • 0.75 mg / 0.5 mL
  • 1.5 mg / 0.5 mL
  • 3 mg / 0.5 mL
  • 4.5 mg / 0.5 mL

2. What is Trulicity?

Trulicity is an injectable medication used together with diet and exercise to improve blood sugar control in:

• Adults with type 2 diabetes mellitus
• Children 10 years and older with type 2 diabetes

It is also used in adults with type 2 diabetes who have cardiovascular disease or multiple risk factors to reduce the risk of serious heart events such as heart attack or stroke.

3. How Trulicity Works

Trulicity mimics a natural hormone called GLP-1 (glucagon-like peptide-1).

It helps the body by:

• Increasing insulin release when blood sugar is high
• Reducing glucose production in the liver
• Slowing gastric emptying
• Reducing appetite

Unlike natural GLP-1, which lasts only minutes, Trulicity works for about one week, allowing once-weekly dosing.

4. Available Dosages

Trulicity is supplied in different strengths for stepwise treatment:

• 0.75 mg / 0.5 mL – starting dose
• 1.5 mg / 0.5 mL – maintenance dose
• 3 mg / 0.5 mL – intermediate dose for additional control
• 4.5 mg / 0.5 mL – maximum available dose

5. How to Use Trulicity

• Inject once weekly on the same day
• Can be taken with or without food
• Inject under the skin (abdomen, thigh, or upper arm)
• Rotate injection sites each week
• Do not mix with insulin in the same injection

Missed Dose Instructions

• If missed and ≥3 days remain, take it as soon as possible
• If <3 days remain, skip and continue schedule
• Do not take two doses within 3 days

6. Common Side Effects

• Nausea
• Diarrhea
• Vomiting
• Abdominal pain
• Decreased appetite

7. Serious Side Effects & Warnings

Trulicity may cause serious health risks in some cases:

Thyroid Tumor Risk

• Possible risk observed in animal studies
• Do not use if history of medullary thyroid carcinoma or MEN 2

Pancreatitis

• Severe abdominal pain may indicate pancreas inflammation

Low Blood Sugar

Symptoms include:

• Dizziness
• Sweating
• Confusion
• Fast heartbeat
• Shaking

Allergic Reactions

• Swelling of face or throat
• Rash or itching
• Trouble breathing

Other Risks

• Kidney problems (due to dehydration)
• Gallbladder disease
• Vision changes
• Stomach emptying issues during surgery

8. Who Should Not Use Trulicity?

Do not use if:

• You have type 1 diabetes
• You have diabetic ketoacidosis
• You are allergic to dulaglutide
• You have MEN 2 or thyroid cancer history

9. Important Medical Considerations

Tell your healthcare provider if you have:

• Kidney or liver disease
• Pancreas problems
• Severe stomach disorders
• Eye disease (diabetic retinopathy)
• Pregnancy or breastfeeding status
• Planned surgery

10. Pregnancy & Breastfeeding

• Unknown if Trulicity harms unborn babies
• Unknown if it passes into breast milk
• Use only under medical supervision

11. Storage Instructions

• Store in refrigerator (2°C–8°C)
• Do not freeze
• Protect from light
• May be stored at room temperature for up to 14 days
• Single-use only

12. Drug Interactions

Trulicity may interact with:

• Insulin
• Sulfonylureas
• Oral medications (delayed absorption due to slower digestion)

Always inform your healthcare provider about all medications.

13. Overdose & Emergency

• Overdose may cause severe nausea, vomiting, or hypoglycemia
• Seek emergency medical help immediately if suspected

14. Manufacturer

Trulicity is manufactured by Eli Lilly and Company.

15. Availability

For availability and supply information:

👉 https://clinicalrxcenter.com